en فیزیولوژی ورزشی Sport Physiology Research Article Research Article <div style="text-align: justify;"><span style="font-size:12px;"><span style="font-family:Times New Roman;"><span style="line-height:200%"><span calibri=""><b><span style="line-height:200%"><span new="" roman="" times="">Background</span></span></b><span style="line-height:200%"><span new="" roman="" times="">: Studies have reported contradictory results regarding the relationship between serum neurofilament light chain (NFL) and fatigue severity. The aim of our study was to investigate serum NFL and fatigue severity in patients with multiple sclerosis (MS) after home-based and outdoor Pilates training.</span></span></span></span><br> <span style="line-height:200%"><span calibri=""><b><span style="line-height:200%"><span new="" roman="" times="">Methods:</span></span></b><span style="line-height:200%"><span new="" roman="" times=""> The study population consisted of 44 women with MS (aged 25 to 40 years) with an expanded disability status scale score of 2-5. The patients were randomly divided into three groups: home-based training (HPT, n=15), outdoor training (OPT, n=15), and a control group (n=14). The training groups performed Pilates exercises for 8 weeks individually at home and under the sun. Blood samples and completed Fatigue Severity Scale forms were taken 48 hours before the first session and after the 8-week intervention. </span></span></span></span><br> <span style="line-height:200%"><span calibri=""><b><span style="line-height:200%"><span new="" roman="" times="">Results:</span></span></b><span style="line-height:200%"><span new="" roman="" times=""> The results showed that OPT caused a more notable increase in serum vitamin D (32.76&plusmn;5.13, <i>p</i><0.001) and a decrease in NFL (15.98&plusmn;2.26, <i>p</i> <0.001) and FSS score (2.51&plusmn;0.35, <i>p</i><0.001) compared with HPT. Also, HPT lowered NFL (18.01&plusmn;2.28, <i>p</i><0.001) and FSS score (3.84&plusmn;0.98, <i>p</i><0.001) compared with the control group. </span></span></span></span><br> <span style="line-height:200%"><span calibri=""><b><span style="line-height:200%"><span new="" roman="" times="">Conclusion:</span></span></b><span style="line-height:200%"><span new="" roman="" times=""> Pilates training can reduce NFL levels and FSS scores in women with MS. In addition, OPT is more effective than HPT in reducing NFL and FSS and increasing vitamin D levels.</span></span></span></span></span></span></div> Exercise Movement Techniques,Neurofilament Protein,vitamin D,fatigue,Multiple Sclerosis, 55 62 http://mlj.goums.ac.ir/browse.php?a_code=A-10-1301-1&slc_lang=en&sid=1 faranak Balaghi Inaloo faranakbalaghi70@gmail.com 100319475328460032013 100319475328460032013 Yes Faculty of Sports Sciences, Hakim Sabzevari University, Sabzevar, Iran Roya Askari r.askari@hsu.ac.ir 100319475328460032014 100319475328460032014 No Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran Amir hossein Haghighi ah.haghighi292@yahoo.com 100319475328460032015 100319475328460032015 No Department of Sports Physiology, Hakim Sabzevari University, Sabzevar, Iran Kaveh kashani Kave57m@gmail.com 100319475328460032016 100319475328460032016 No Neurologist, Fars Province, Fasa, Iran Paul Friedemann friedemann.paul@charite.de 100319475328460032017 100319475328460032017 No Neurologist and Scientific Director of the Experimental and Clinical Research Center (ECRC), Charité – Universitätsmedizin Berlin, Germany