en پزشکی عمومى General medicine تحقیقی Original article <div style="text-align: justify;"><strong>Background</strong>: Alzheimer&#39;s is a neurodegenerative disorder characterized by memory loss and cognitive dysfunction. Research has shown that blood metal levels and physical activity may be key to injury and possibly Alzheimer&#39;s treatment. The aim of this study was to investigate the effects of high intensity interval training (HIIT) and Folate Nano-liposome on the expression of D1 and D2 receptors in the hippocampal tissue of Alzheimer&#39;s rats.<span dir="RTL"></span><br> <strong>Methods</strong>: Thirty<span dir="RTL">-</span>three male Wistar rats at the age of eight weeks were prepared from Pasteur Institute. Rats were randomly divided into 5 groups (healthy control, Alzheimer&#39;s control, Alzheimer+ HIIT, Alzheimer +Folate Nano liposomes, Alzheimer+ HIIT +Folate Nano liposomes).Alzheimer&#39;s induction was performed and Folate Nano-liposomes were injected as a supplement .After the last training session, rats were anesthetized and the hippocampus was analyzed.<br> <strong>Results</strong>: The results of one-way ANOVA showed a significant increase between the groups in D1 mRNA and D2 mRNA (P&le;0.000). The results of the Bonferroni post hoc test showed that there was a significant increase the control group and the Alzheimer&#39;s, Alzheimer&#39;s + HIIT and Alzheimer&#39;s +folate Nano liposomes. There was a significant increase between Alzheimer&#39;s group and Alzheimer&#39;s+ HIIT and Alzheimer&#39;s+ HIIT+ folate Nano-liposomes (P&le;0.05).<br> <strong>Conclusion</strong>: Resistance training and Folate Nano-liposomes have changed the content of D1 and D2 in the brain after Alzheimer&#39;s induction. These changes may be due in part to the synergistic effect of physical activity and Nano-pharmaceuticals in preventing or reducing the detrimental effects of pathological conditions. <span dir="RTL"></span></div> Exercise,Receptors Dopamine,Dietary Supplements,Immune System, 36 44 http://goums.ac.ir/jorjanijournal/browse.php?a_code=A-10-787-5&slc_lang=en&sid=1 farah nameni nameni@iauvaramin.ac.ir 10031947532846007923 10031947532846007923 Yes Department of Sport Physiology, Varamin Pishva Branch, Islamic Azad University Fateme Firoozmand mefiroozmand@gmail.com 10031947532846007924 10031947532846007924 No MSc. of Sport Physiology, Varamin Pishva Branch, Islamic Azad University